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Transforming clinical apheresis waste into a renewable source of patient-derived CD34+ hematopoietic stem cell biobank for beta-hemoglobinopathy research and therapeutic discovery

2026-08-04

Abstract excerpt

<h4>Background aims</h4> The development of next-generation therapies for sickle cell disease (SCD) and beta thalassemia (beta thal), including fetal globin–inducing small molecules and gene therapy approaches, depends on patient-derived CD34+ hematopoietic stem and progenitor cells (HSPCs) for discovery and preclinical validation, but commercial vendors stock only healthy donor material and disease-specific bank...

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Literature Corpus work: 1b4ad120-facd-5065-afc8-816b818ce98f
DOI: 10.64898/2026.08.02.742313

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