Article

Optimizing CD34+ cell doses for large-scale translational, single donor humanized mouse experiments

2025-04-30

Abstract excerpt

<title>Abstract</title> <p>Humanized mice are a powerful tool in preclinical assessment of novel therapeutics. However, generation of large homogenous cohorts is believed to be hampered by the limited number of human stem cells retrievable from individual donors, like from umbilical cord blood specimens. Here, we present a streamlined CD34+ cell isolation method that improves yield and purity compared to standard...

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Literature Corpus work: 0272750e-381c-5e79-b6a8-b7d7d317e63a
DOI: 10.21203/rs.3.rs-6382310/v1

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