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Disease severity impacts plerixafor-mobilized stem cell collection in patients with sickle cell disease

6 May 2021

Abstract excerpt

Recent studies suggest that plerixafor mobilization and apheresis in patients with sickle cell disease (SCD) is safe and can allow collection of sufficient CD34+ hematopoietic stem cell (HSC) collection for clinical gene therapy applications. However, the quantities of plerixafor-mobilized CD34+ cells vary between different SCD patients for unknown reasons. Twenty-three participants with SCD underwent plerixafor...

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PMID: 33956057
DOI: 10.1182/bloodadvances.2021004232

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