Article

A two-level, dynamic fitness landscape of hepatitis C virus revealed by self-organized haplotype maps

2021-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Fitness landscapes reflect the adaptive potential of viruses. There is no information on how fitness peaks evolve when a virus replicates extensively in a controlled cell culture environment. Here we report the construction of Self-Organized Maps (SOMs), based on deep sequencing reads of three amplicons of the NS5A-NS5B-coding region of hepatitis C virus (HCV). A two-dimensional neural network w...

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Literature Corpus work: 1b1929a5-01f5-59f1-a1ed-c6f8c610c913
DOI: 10.1101/2021.04.22.441053

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