Article
A Two-Level, Intramutant Spectrum Haplotype Profile of Hepatitis C Virus Revealed by Self-Organized Maps.
Microbiology spectrum - 22 Dec 2021
Delgado Soledad, Perales Celia, García-Crespo Carlos, Soria María Eugenia, Gallego Isabel, de Ávila Ana Isabel, Martínez-González Brenda, Vázquez-Sirvent Lucía, López-Galíndez Cecilio, Morán Federico, Domingo Esteban
Abstract excerpt
RNA viruses replicate as complex mutant spectra termed viral quasispecies. The frequency of each individual genome in a mutant spectrum depends on its rate of generation and its relative fitness in the replicating population ensemble. The advent of deep sequencing methodologies allows for the first-time quantification of haplotype abundances within mutant spectra. There is no information on the haplotype profile...
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