Article

NK Cells Engineered with a Chimeric Antigen Receptor Delay HIV Rebound and Reshape HIV Reservoir Composition

2026-01-24

Abstract excerpt

Durable HIV remission will require strategies that eliminate or permanently silence the latent reservoir that persists despite antiretroviral therapy (ART). Natural killer (NK) cells possess inherent antiviral activity, but unmodified NK cells have limited ability to recognize or clear latently infected cells during ART suppression. We engineered allogeneic human primary NK cells expressing a truncated CD4-based c...

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Literature Corpus work: 1abe9b39-72a3-5920-a3ff-88778318e937
DOI: 10.64898/2026.01.22.700964

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