Article

Aging with TBI vs. Aging: 6-month temporal profiles for neuropathology and astrocyte activation converge in behaviorally relevant thalamocortical circuitry of male and female rats

2023-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Traumatic brain injury (TBI) manifests late-onset and persisting clinical symptoms with implications for sex differences and increased risk for the development of age-related neurodegenerative diseases. Few studies have evaluated chronic temporal profiles of neuronal and glial pathology that include sex as a biological variable. After experimental diffuse TBI, late-onset and persisting somatosen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ab94fd7-2c7a-53fe-bfe4-c881424d765c
DOI: 10.1101/2023.02.06.527058

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging with TBI vs. Aging: 6-month temporal profiles for neuropathology and astrocyte activation converge in behaviorally relevant thalamocortical circuitry of male and female ratsDOI 10.1101/2023.02.06.527058Read

Distinct expression profile reveals glia involvement in the trigeminal system attributing to post-traumatic headacheSemantic proximity Read

Epilepsy phenotype and its reproducibility after lateral fluid percussion-induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1.Semantic proximity Read

A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.Semantic proximity Read

Enriching neural stem cell and anti-inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats.Semantic proximity Read

Evidence for the Transient Presence of Atypical Astrocytes in Mice Following a Single, Closed-Head Mild Traumatic Brain InjurySemantic proximity Read

Mild traumatic brain injury induces transient, sequential increases in proliferation, neuroblasts/immature neurons, and cell survival: a time course study in the male mouse dentate gyrusSemantic proximity Read

Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head traumaSemantic proximity Read

A larval zebrafish model of TBI: Optimizing the dose of neurotrauma for discovery of treatments and aetiologySemantic proximity Read

The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.Semantic proximity Read

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in PigsSemantic proximity Read

Functional assessment of long-term deficits in rodent models of traumatic brain injury.Semantic proximity Read

Cerebral hypoperfusion exacerbates traumatic brain injury in male but not female miceSemantic proximity Read