Epilepsy phenotype and its reproducibility after lateral fluid percussion-induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1.

doi:10.1111/epi.17838

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Epilepsy phenotype and its reproducibility after lateral fluid percussion-induced traumatic brain injury in rats: Multicenter EpiBioS4Rx study project 1.

Epilepsia - 1 Feb 2024

Ndode-Ekane Xavier Ekolle, Ali Idrish, Santana-Gomez Cesar, Andrade Pedro, Immonen Riikka, Casillas-Espinosa Pablo, Paananen Tomi, Manninen Eppu, Puhakka Noora, Smith Gregory, Brady Rhys D, Silva Juliana, Braine Emma, Hudson Matt, Yamakawa Glen R, Jones Nigel C, Shultz Sandy R, Harris Neil, Wright David K, Gröhn Olli, Staba Richard, O'Brien Terence J, Pitkänen Asla

Abstract excerpt

OBJECTIVE: This study was undertaken to assess reproducibility of the epilepsy outcome and phenotype in a lateral fluid percussion model of posttraumatic epilepsy (PTE) across three study sites. METHODS: A total of 525 adult male Sprague Dawley rats were randomized to lateral fluid percussion-induced brain injury (FPI) or sham operation. Of these, 264 were assigned to magnetic resonance imaging (MRI cohort, 43...

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Identifiers

PMID: 38052475
DOI: 10.1111/epi.17838
PMCID: PMC10922674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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