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The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury.

Molecular neurobiology - 1 Nov 2018

Crespo-Castrillo Andrea, Yanguas-Casás Natalia, Arevalo Maria Angeles, Azcoitia Iñigo, Barreto George E, Garcia-Segura Luis M

Abstract excerpt

Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric...

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PMID: 29582398
DOI: 10.1007/s12035-018-1008-x

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GFAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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