Article
Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion.
Communications biology - 4 Feb 2022
Aulicino Anna, Antanaviciute Agne, Frost Joe, Sousa Geros Ana, Mellado Esther, Attar Moustafa, Jagielowicz Marta, Hublitz Philip, Sinz Julia, Preciado-Llanes Lorena, Napolitani Giorgio, Bowden Rory, Koohy Hashem, Drakesmith Hal, Simmons Alison
Abstract excerpt
Salmonella enterica represent a major disease burden worldwide. S. enterica serovar Typhi (S. Typhi) is responsible for potentially life-threatening Typhoid fever affecting 10.9 million people annually. While non-typhoidal Salmonella (NTS) serovars usually trigger self-limiting diarrhoea, invasive NTS bacteraemia is a growing public health challenge. Dendritic cells (DCs) are key professional antigen presenting...
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