Article

Biallelic loss of LDB3 leads to a lethal pediatric dilated cardiomyopathy

2022-06-13

Abstract excerpt

<title>Abstract</title> <p>Autosomal dominant variants in <italic>LDB3</italic> (also known as ZASP), encoding the PDZ-LIM domain-binding factor, have been linked to a late onset phenotype of cardiomyopathy and myofibrillar myopathy in humans. However, despite knockout mice displaying a much more severe phenotype with premature death, bi-allelic variants in <italic>LDB3</italic> have not yet been reported. Here w...

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Literature Corpus work: 57694482-645f-5dd9-ba9f-90dcd8d6aafd
DOI: 10.21203/rs.3.rs-1699263/v1

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