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Article

The Role of Z-disc Proteins in Myopathy and Cardiomyopathy.

International journal of molecular sciences - 17 Mar 2021

Wadmore Kirsty, Azad Amar J, Gehmlich Katja

Abstract excerpt

The Z-disc acts as a protein-rich structure to tether thin filament in the contractile units, the sarcomeres, of striated muscle cells. Proteins found in the Z-disc are integral for maintaining the architecture of the sarcomere. They also enable it to function as a (bio-mechanical) signalling hub. Numerous proteins interact in the Z-disc to facilitate force transduction and intracellular signalling in both...

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Identifiers

PMID: 33802723
DOI: 10.3390/ijms22063058
PMCID: PMC8002584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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