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Article

Mining Predicted Essential Genes of Brugia malayi for Nematode Drug Targets

13 Nov 2007

Abstract excerpt

We report results from the first genome-wide application of a rational drug target selection methodology to a metazoan pathogen genome, the completed draft sequence of Brugia malayi, a parasitic nematode responsible for human lymphatic filariasis. More than 1.5 billion people worldwide are at risk of contracting lymphatic filariasis and onchocerciasis, a related filarial disease. Drug treatments for filariasis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18000556
DOI: 10.1371/journal.pone.0001189

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