Article

Loss of Kallmann syndrome-associated gene WDR11 disrupts primordial germ cell development by affecting canonical and non-canonical Hedgehog signalling

2020-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations of WDR11 are associated with Kallmann syndrome (KS) and congenital hypogonadotrophic hypogonadism (CHH), typically caused by defective functions of gonadotrophin-releasing hormone (GnRH) neurones in the brain. We previously reported that Wdr11 knockout mice show profound infertility with significantly fewer germ cells present in the gonads. To understand the underlying mechanisms medi...

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Literature Corpus work: 1a3e9528-91a1-5a91-a5bf-b61c808cfc45
DOI: 10.1101/2020.09.06.284927

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