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Article

GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.

PLoS genetics - 1 Jun 2020

Kothandapani Anbarasi, Lewis Samantha R, Noel Jessica L, Zacharski Abbey, Krellwitz Kyle, Baines Anna, Winske Stephanie, Vezina Chad M, Kaftanovskaya Elena M, Agoulnik Alexander I, Merton Emily M, Cohn Martin J, Jorgensen Joan S

Abstract excerpt

Urogenital tract abnormalities are among the most common congenital defects in humans. Male urogenital development requires Hedgehog-GLI signaling and testicular hormones, but how these pathways interact is unclear. We found that Gli3XtJ mutant mice exhibit cryptorchidism and hypospadias due to local effects of GLI3 loss and systemic effects of testicular hormone deficiency. Fetal Leydig cells, the sole source of...

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Share to Cryptorchidism
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Zinc Finger Protein Gli3

Source

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Identifiers

PMID: 32497091
DOI: 10.1371/journal.pgen.1008810
PMCID: PMC7297385

Genes

GLI3
INSL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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