Article

Reconstructing Cytokine Storm Dynamics: A Systems Immunology Framework Based on Danger Load and Immune Buffer Capacity

2026-06-05

Abstract excerpt

Cytokine storm syndromes arise from a systemic collapse of immune homeostasis due to dynamic imbalance between danger load (L) and immune buffer capacity (B). Existing linear “danger signal → inflammation” models cannot explain why high antigen loads sometimes produce only mild inflammation, why hyperinflammation and immunosuppression often co‑exist, or why similar danger signals lead to divergent clinical outcome...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a33e6bf-6da8-5736-87e6-0392256bb5e5
DOI: 10.20944/preprints202606.0490.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reconstructing Cytokine Storm Dynamics: A Systems Immunology Framework Based on Danger Load and Immune Buffer CapacityDOI 10.20944/preprints202606.0490.v1Read

Cytokine Storm SyndromeSemantic proximity Read

Cytokine Overproduction and Immune System Dysregulation in alloHSCT and COVID-19 PatientsSemantic proximity Read

Toward a Unified Conceptual Framework for Flare–Remission Dynamics in Autoimmune Diseases: A Treg–Tpex Oscillation and Dual-Threshold ModelSemantic proximity Read

Multiscale Information Processing in the Immune SystemSemantic proximity Read

CytokineLink: a cytokine communication map to analyse immune responses in inflammatory and infectious diseasesSemantic proximity Read

Bistable attractor dynamics in difficult-to-treat rheumatic disease: a multi-axis ODE framework with cross-disease transcriptomic evidenceSemantic proximity Read

The Immunity Hallmarks Matrix: A Generative Grammar for ImmunopharmacologySemantic proximity Read

Inflammation Joins the “Niche”Semantic proximity Read

Are superantigens the cause of cytokine storm and viral sepsis in severe COVID‐19? Observations and hypothesisSemantic proximity Read

Inflammatory Load-Driven Bistability of Maternal–Fetal Immune Tolerance: A Unified Framework for Pregnancy ComplicationsSemantic proximity Read

Cytokine storm and sepsis disease pathogenesis.Semantic proximity Read

Critical Dynamics of Peripheral Immune Tolerance: A Treg-Tpex Antagonism Framework for Phase Transition and Immune State StratificationSemantic proximity Read