Back to search

Article

Inflammatory Load-Driven Bistability of Maternal–Fetal Immune Tolerance: A Unified Framework for Pregnancy Complications

2026-06-23

Abstract excerpt

Maternal tolerance of the semi-allogeneic fetus is fundamental to successful pregnancy, yet traditional “immune suppression” models fail to explain three key clinical phenomena: the marked heterogeneity in pregnancy outcomes, the abrupt and refractory onset of preeclampsia, and the increased incidence of autoimmune diseases in the postpartum period. Here we propose a conceptual theoretical framework—the “inflammat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
93632448-ef99-5b4f-a86e-cca3c97972af
DOI
10.20944/preprints202606.1469.v2
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inflammatory Load-Driven Bistability of Maternal–Fetal Immune Tolerance: A Unified Framework for Pregnancy ComplicationsDOI 10.20944/preprints202606.1469.v2
Inflammatory Burden–Driven Bistability of Maternal–Fetal Immune Tolerance: A Framework for Pregnancy ComplicationsSemantic proximity
Regulatory T Cells: New Keys for Further Unlocking the Enigma of Fetal Tolerance and Pregnancy ComplicationsSemantic proximity
The landscape of decidual immune cells at the maternal–fetal interface in parturition and preterm birthSemantic proximity
Searching for influencers among placental immune cells in preeclampsiaSemantic proximity
A dynamic peripheral immune landscape during human pregnancySemantic proximity
On the Similarity Between Postpartum Autoimmune Abnormalities and Immune-Related Adverse Events (irAE) by Immune Checkpoint Inhibitors (ICI): The Placenta as a PD-L1-Rich Immune-Tolerant OrganSemantic proximity
The New Old CD8+ T Cells in the Immune Paradox of PregnancySemantic proximity
Human placental villi immune cells help maintain homeostasis <i>in utero</i>Semantic proximity
Mechanisms of Fetal T Cell Tolerance and Immune RegulationSemantic proximity
Prenatal stress, anxiety and depression alter transcripts, proteins and pathways associated with immune responses at the maternal-fetal interfaceSemantic proximity
Innate Lymphoid Cells at the Maternal-Fetal Interface in Human PregnancySemantic proximity
Roles of γδT cells in pregnancy and pregnancy-related complications.Semantic proximity
Select a neighboring publication to make it the new centre.