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Article

Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents.

Cancer discovery - 1 Apr 2012

Birkbak Nicolai J, Wang Zhigang C, Kim Ji-Young, Eklund Aron C, Li Qiyuan, Tian Ruiyang, Bowman-Colin Christian, Li Yang, Greene-Colozzi April, Iglehart J Dirk, Tung Nadine, Ryan Paula D, Garber Judy E, Silver Daniel P, Szallasi Zoltan, Richardson Andrea L

Abstract excerpt

UNLABELLED: DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs, such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome damage during growth and also can repair platinum-induced DNA damage. We sought genomic signatures indicative of defective DNA repair in cell lines and tumors and correlated these signatures to platinum sensitivity. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22576213
DOI: 10.1158/2159-8290.CD-11-0206
PMCID: PMC3806629

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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