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Article

Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression.

Journal for immunotherapy of cancer - 1 Jan 2021

Natoli Marina, Gallon John, Lu Haonan, Amgheib Ala, Pinato David J, Mauri Francesco A, Marafioti Teresa, Akarca Ayse U, Ullmo Ines, Ip Jacey, Aboagye Eric O, Brown Robert, Karadimitris Anastasios, Ghaem-Maghami Sadaf

Abstract excerpt

BACKGROUND: Endogenous retroviruses (ERVs) play a role in a variety of biological processes, including embryogenesis and cancer. DNA methyltransferase inhibitors (DNMTi)-induced ERV expression triggers interferon responses in ovarian cancer cells via the viral sensing machinery. Baseline expression of ERVs also occurs in cancer cells, though this process is poorly understood and previously unexplored in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33436485
DOI: 10.1136/jitc-2020-001519
PMCID: PMC7805370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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