Article

Uzatresgene autoleucel autologous T-cell monotherapy for advanced solid tumors: SURPASS, a phase 1, open-label trial

2026-04-03

Abstract excerpt

<title>Abstract</title> <p> Uzatresgene autoleucel (uza-cel), a next-generation engineered T-cell receptor autologous T-cell therapy, targets melanoma-associated antigen (MAGE) A4 widely presented by human leukocyte antigens (HLA) on solid tumors. This phase 1, open-label trial evaluated uza-cel in adult HLA-eligible patients with advanced, previously treated MAGE-A4–positive solid tumors. In the monotherapy coh...

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Literature Corpus work: cd95b2a9-ad2b-5645-98fc-c659b7bf832a
DOI: 10.21203/rs.3.rs-9238113/v1

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