Article

An Epstein-Barr virus-encoded snoRNA directs 2’-O-methylation of human rRNAs to control translation and the viral lytic switch

2026-05-13

Abstract excerpt

<h4>Summary</h4> Epstein-Barr virus (EBV) establishes life-long latency in human B-cells yet the molecular strategies that balance its persistence with lytic replication remain incompletely understood. Here, we identify the EBV-encoded small nucleolar RNA, v-snoRNA1, as a bona fide 2′-O-methylation guide that directs methylation of host ribosomal RNAs at 18S-C621 and 28S-U1760, two conserved residues in the ribo...

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Literature Corpus work: af6c888f-6eee-5cf1-8e13-82e9ac630fc0
DOI: 10.64898/2026.05.13.724956

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An Epstein-Barr virus-encoded snoRNA directs 2’-O-methylation of human rRNAs to control translation and the viral lytic switchDOI 10.64898/2026.05.13.724956Read

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