Article

Beyond the reference: gene expression variation and transcriptional response to RNAi in <i>C. elegans</i>

2023-03-25

Abstract excerpt

A universal feature of living systems is that natural variation in genotype underpins variation in phenotype. Yet, research in model organisms is often constrained to a single genetic background, the reference strain. Further, genomic studies that do evaluate wild strains typically rely on the reference strain genome for read alignment, leading to the possibility of biased inferences based on incomplete or inaccur...

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Literature Corpus work: 0fbc94eb-6337-5d3a-8511-3fe2a97194e3
DOI: 10.1101/2023.03.24.533964

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