Article

Deacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance

2021-07-16

Abstract excerpt

<title>Abstract</title> <p>Acquired chemoresistance to proteasome inhibitors (PIs) is a major obstacle that results in failure to manage patients with multiple myeloma (MM) in the clinic; however, the key regulators and underlying mechanisms are still unclear. In this study, we found that high levels of a chromosomal modifier, heterochromatin protein 1 gamma (HP1γ), are accompanied by a low acetylation level in b...

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Literature Corpus work: 194dd1ca-28de-5609-a06a-3532ef960b05
DOI: 10.21203/rs.3.rs-698350/v1

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