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The biological significance of histone modifiers in multiple myeloma: clinical applications

22 Aug 2018

Abstract excerpt

Multiple myeloma (MM) is a clonal plasma cell disorder that is characterized by a variety of genetic alterations. Recent studies have highlighted not only the importance of these genetic events but also epigenetic aberrations including DNA methylation, histone modifications, and non-coding RNAs in the biology of MM. Post-translational modifications of histone, such as methylation and acetylation, contribute to...

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PMID: 30190472
DOI: 10.1038/s41408-018-0119-y

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