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Total Neoadjuvant Therapy and Organ Preservation in Locally Advanced Rectal Cancer: A State-of-the-Art Systematic Review and Critical Appraisal

2026-04-14

Abstract excerpt

Evidence indicates that the management of locally advanced rectal cancer (LARC) has shifted from a surgery-centric model to a response-adaptive paradigm centered on total neoadjuvant therapy (TNT). This state-of-the-art review synthesizes contemporary evidence from 45 publications across 30 trials, critically evaluating TNT's efficacy, toxicity, impact on organ preservation (OP), and predictive biomarkers. We...

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Literature Corpus work
e8133c18-e6a7-548a-9c3c-193cc83301c2
DOI
10.20944/preprints202604.0881.v1
Open publication

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