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New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy

2023-04-13

Abstract excerpt

Rectal cancer ranks as the second leading cause of cancer-related deaths. Neoadjuvant therapy for rectal cancer patients often results in individuals that respond well to therapy and those that respond poorly, requiring life-altering excision surgery. It is inadequately understood what dictates this responder/nonresponder divide. Our major aim is to identify what factors in the tumor microenvironment drive a fract...

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Literature Corpus work
5c2b5666-2a4c-5452-80e8-4eafcb32d849
DOI
10.21203/rs.3.rs-2767780/v1
Open publication

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