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CRISPR/Cas9 Genome Editing to Disable the Latent HIV-1 Provirus

14 Dec 2018

Abstract excerpt

HIV-1 infection can be successfully controlled with anti-retroviral therapy (ART), but is not cured. A reservoir of cells harboring transcriptionally silent integrated provirus is able to reestablish replicating infection if ART is stopped. Latently HIV-1 infected cells are rare, but may persist for decades. Several novel strategies have been proposed to reduce the latent reservoir, including DNA sequence...

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PMID: 30619186
DOI: 10.3389/fmicb.2018.03107

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