Article

DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage

2025-11-11

Abstract excerpt

<h4>ABSTRACT</h4> DNA methylation (5mC) is an epigenetic mark that plays a critical role in defining cell fate. Following fertilisation, DNA methylation inherited from gametes must be reprogrammed to establish totipotency and enable the parental-to-zygotic transition. To accomplish this, non-mammalian vertebrates such as zebrafish and medaka subtly reprogram maternal 5mC profiles while maintaining high methylatio...

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Literature Corpus work: 19351b5e-aecf-51c5-8cf8-9c386789fec0
DOI: 10.1101/2025.11.09.686659

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