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Article

Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies.

The journal of obstetrics and gynaecology research - 1 Jul 2016

Oda Katsutoshi, Ikeda Yuji, Kashiyama Tomoko, Miyasaka Aki, Inaba Kanako, Fukuda Tomohiko, Asada Kayo, Sone Kenbun, Wada-Hiraike Osamu, Kawana Kei, Osuga Yutaka, Fujii Tomoyuki

Abstract excerpt

Recent developments in genomic analysis have unveiled the key signaling pathways in human cancer. However, only a limited number of molecular-targeted drugs are applicable for clinical use in gynecologic malignancies. TP53 signaling and phosphatidylinositol 3 kinase pathways are frequently mutated in cancer, and have received much attention as molecular targets in human cancers. In this review, we mainly focus on...

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PMID: 27094348
DOI: 10.1111/jog.13018

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