Article
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia.
Blood - 12 Mar 2015
Maude Shannon L, Dolai Sibasish, Delgado-Martin Cristina, Vincent Tiffaney, Robbins Alissa, Selvanathan Arthavan, Ryan Theresa, Hall Junior, Wood Andrew C, Tasian Sarah K, Hunger Stephen P, Loh Mignon L, Mullighan Charles G, Wood Brent L, Hermiston Michelle L, Grupp Stephan A, Lock Richard B, Teachey David T
Abstract excerpt
Early T-cell precursor (ETP) acute lymphoblastic leukemia (ALL) is a recently described subtype of T-ALL characterized by a unique immunophenotype and genomic profile, as well as a high rate of induction failure. Frequent mutations in cytokine receptor and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathways led us to hypothesize that ETP-ALL is dependent on JAK/STAT...
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