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Article

A small-molecule compound identified through a cell-based screening inhibits JAK/STAT pathway signaling in human cancer cells

1 Sept 2008

Abstract excerpt

Inappropriate activation of JAK/STAT signaling occurs with high frequency in human cancers and is associated with cancer cell survival and proliferation. Therefore, the development of pharmacologic STAT signaling inhibitors has therapeutic potential in the treatment of human cancers. Here, we report 2-[(3,5-bis-trifluoromethyl-phenyl)-hydroxy-methyl]-1-(4-nitro-phenylamino)-6-phenyl-1,2,4a,7a-tetrahydro-pyrrolo[3,...

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Identifiers

PMID: 18790749
DOI: 10.1158/1535-7163.mct-08-0309

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