The Heteromeric Dopamine Receptor D2:D3 Controls the Gut Recruitment and Suppressive Activity of Regulatory T-Cells

Abstract excerpt

Since colonic dopamine levels undergo a sharp reduction in inflammatory bowel disease (IBD) and animal models, we study how dopaminergic signalling affects regulatory T cells (Treg), which are critical limiting gut inflammation. Previously, we showed that the stimulation of the high-affinity dopamine receptor Drd3 impairs the suppressive Treg ac-tivity and limits their colonic tropism upon gut inflammation. Here w...

Topics

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• Alternative Splicing
• Angiogenesis and VEGF in Cancer
• Axon Guidance and Neuronal Signaling
• Dopamine
• Dopamine Antagonists
• GTP-Binding Protein alpha Subunits
• GTP-Binding Protein alpha Subunits, Gi-Go
• Receptors, Dopamine D2

Identifiers and source

Literature Corpus work

188e1f17-ef9a-5a8e-a613-91a1df9733d4

DOI

10.20944/preprints202508.0861.v1