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Article

HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα

10 Sept 2018

Abstract excerpt

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3 ubiquitin ligase...

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Share to Autophagy in Disease and Therapy
Share to Endoplasmic Reticulum Stress and Disease
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PMID: 30217973
DOI: 10.1038/s41467-018-05722-3

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