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Article

Regulation of Thalamic and Cortical Network Synchrony by Scn8a.

Neuron - 8 Mar 2017

Makinson Christopher D, Tanaka Brian S, Sorokin Jordan M, Wong Jennifer C, Christian Catherine A, Goldin Alan L, Escayg Andrew, Huguenard John R

Abstract excerpt

Voltage-gated sodium channel (VGSC) mutations cause severe epilepsies marked by intermittent, pathological hypersynchronous brain states. Here we present two mechanisms that help to explain how mutations in one VGSC gene, Scn8a, contribute to two distinct seizure phenotypes: (1) hypoexcitation of cortical circuits leading to convulsive seizure resistance, and (2) hyperexcitation of thalamocortical circuits...

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Identifiers

PMID: 28238546
DOI: 10.1016/j.neuron.2017.01.031
PMCID: PMC5393918

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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