Article

Towards a platform quantitative systems pharmacology (QSP) model for preclinical to clinical translation of antibody drug conjugates (ADCs)

2022-12-15

Abstract excerpt

<title>Abstract</title> <p>A next generation multiscale quantitative systems pharmacology (QSP) model for antibody drug conjugates (ADCs) is presented, for preclinical to clinical translation of ADC efficacy. Two HER2 ADCs (trastuzumab-DM1 and trastuzumab-DXd) were used for model development, calibration, and validation. The model integrates drug specific experimental data including in vitro cellular disposition...

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Literature Corpus work: 185098ab-a348-5a6c-9e19-df9188be95b1
DOI: 10.21203/rs.3.rs-2371793/v1

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