Article

A reproducible molecular dynamics benchmark for ADC epitope triage in EGFR and HER2

2026-02-10

Abstract excerpt

<title>Abstract</title> <p>Antibody–drug conjugate programs often commit to an epitope before peptide–level experimental evidence is available. I present a reproducible molecular–dynamics benchmark for pre–HDX epitope triage in EGFR and HER2, evaluated on three therapeutic antibody–antigen pairs (HER2–Trastuzumab, EGFR–Cetuximab, and EGFR–Panitumumab). For each system, paired simulations of antigen alone and anti...

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Literature Corpus work: d4d94fd0-024f-53b7-a252-e699c00e7277
DOI: 10.21203/rs.3.rs-8820222/v1

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