Article

Structural basis of nirmatrelvir and ensitrelvir resistance profiles against SARS-CoV-2 Main Protease naturally occurring polymorphisms

2022-09-01

Abstract excerpt

SARS-CoV-2 is the causative agent of COVID-19. M pro is the main viral protease, with a critical role in replication and, therefore, an attractive target for antiviral drug discovery. The clinically approved drug nirmatrelvir from Pfizer, and the clinical candidate ensitrelvir from Shionogi Pharmaceuticals had so far showed great potential for treatment of viral infections. Despite the importance of new therapeut...

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Literature Corpus work: 18113d84-fbe0-5f2a-b5e7-da44b789863d
DOI: 10.1101/2022.08.31.506107

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