Article

ADMET-Guided Design and In-Silico Planning of Boron Delivery Systems for BNCT: From Transport and Biodistribution to PBPK-Informed Irradiation Windows

2025-12-17

Abstract excerpt

In this review, we examine boron-containing agents for boron neutron capture therapy (BNCT) with a focus on absorption, distribution, metabolism, excretion and toxicity (ADMET) and model-informed design. BNCT is a binary radiotherapeutic modality in which high linear energy transfer particles are generated in the vicinity of ^10B, ideally within boron-loaded tumour cells, so the therapeutic outcome depends critica...

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Literature Corpus work: 1469a73f-8c0b-57de-84d3-2eb8d6a00660
DOI: 10.20944/preprints202512.1586.v1

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