Article

Systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genes

2019-12-17

Abstract excerpt

Many gene families have been expanded by gene duplications along the human lineage, relative to ancestral opisthokonts, but the extent to which the duplicated genes function similarly is understudied. Here, we focused on structural cytoskeletal genes involved in critical cellular processes including chromosome segregation, macromolecular transport, and cell shape maintenance. To determine functional redundancy and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1791e162-4001-5cfc-9954-69cd6a1be1a3
DOI: 10.1101/2019.12.16.878751

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic humanization of the yeast cytoskeleton discerns functionally replaceable from divergent human genesDOI 10.1101/2019.12.16.878751Read

Systematic Humanization of the Yeast Cytoskeleton Discerns Functionally Replaceable from Divergent Human Genes.Semantic proximity Read

The phenotypic landscape of essential human genesSemantic proximity Read

Modeling complex genetic interactions in a simple eukaryotic genome: actin displays a rich spectrum of complex haploinsufficiencies.Semantic proximity Read

Invivo and systematic analysis of random multigenic deletions associated with human diseases during epithelial morphogenesis in DrosophilaSemantic proximity Read

Novel interactions between actin and the proteasome revealed by complex haploinsufficiency.Semantic proximity Read

Humanization of yeast genes with multiple human orthologs reveals principles of functional divergence between paralogsSemantic proximity Read

Yeast as a Model to Understand Actin-Mediated Cellular Functions in Mammals—Illustrated with Four Actin Cytoskeleton ProteinsSemantic proximity Read

Revisiting the Phylogeny of the Animal Formins: Two New Subtypes, Relationships with Multiple Wing Hairs Proteins, and a Lost Human ForminSemantic proximity Read

Humanized yeast to model human biology, disease and evolution.Semantic proximity Read

Human subtelomeric WASH genes encode a new subclass of the WASP family.Semantic proximity Read

How myosin organization of the actin cytoskeleton contributes to the cancer phenotype.Semantic proximity Read

Lost in the WASH. The functional human WASH complex 1 gene is on chromosome 20Semantic proximity Read