Article
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.
Journal of neuroscience methods - 1 Aug 2018
Perni Michele, Challa Pavan K, Kirkegaard Julius B, Limbocker Ryan, Koopman Mandy, Hardenberg Maarten C, Sormanni Pietro, Müller Thomas, Saar Kadi L, Roode Lianne W Y, Habchi Johnny, Vecchi Giulia, Fernando Nilumi, Casford Samuel, Nollen Ellen A A, Vendruscolo Michele, Dobson Christopher M, Knowles Tuomas P J
Abstract excerpt
BACKGROUND: The nematode worm C. elegans is a model organism widely used for studies of genetics and of human disease. The health and fitness of the worms can be quantified in different ways, such as by measuring their bending frequency, speed or lifespan. Manual assays, however, are time consuming and limited in their scope providing a strong motivation for automation. NEW METHOD: We describe the development and...
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