Article

Vanishing White Matter Disease Expression of Truncated EIF2B5 Activates Induced Stress Response

2020-05-05

Abstract excerpt

Vanishing White Matter disease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B). Current models only partially recapitulate key disease features, and pathophysiology is poorly understood. Through development and validation of zebrafish ( Danio rerio ) models of VWM, we demonstrate that zebrafish eif2b mutants phe...

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Literature Corpus work: 2a26829d-fed8-5bc2-9994-d092f6f956b2
DOI: 10.1101/2020.05.05.078295

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