Article

The Translational Landscape of Reactive Astrocytes Reveals the Impact of eIF2B-mediated Dysregulation in VWM Disease

2025-01-16

Abstract excerpt

A devastating genetic recessive neurodegenerative disorder, Vanishing White Matter Disease (VWMD), stems from mutations in eIF2B—a master regulator of mRNA translation initiation and mediator of cellular stress response. While astrocytes, the brain’s essential support cells, are known to be central to VWMD pathology, the molecular mechanisms underlying their dysfunction remain poorly understood. Our study reveals...

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Literature Corpus work: 028c8c17-92e8-520f-b861-71d37ee74ca4
DOI: 10.1101/2025.01.14.633074

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