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Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

13 Nov 2017

Abstract excerpt

Mechanical strain is a potent stimulus for growth and remodeling in cells. Although many pathways have been implicated in stretch-induced remodeling, the control structures by which signals from distinct mechano-sensors are integrated to modulate hypertrophy and gene expression in cardiomyocytes remain unclear. Here, we constructed and validated a predictive computational model of the cardiac mechano-signaling...

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PMID: 29131824
DOI: 10.1371/journal.pcbi.1005854

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