Article

Quality of vaccination-induced T cell responses is conveyed by polyclonality and high, but not maximum, antigen receptor avidity

2024-10-31

Abstract excerpt

While the quantity of vaccination-induced T cells represents a routine immunogenicity parameter, the quality of such responses is poorly understood. We here report on a clinical cohort of 29 human healthy individuals who received three mRNA vaccinations against SARS-CoV-2 before any breakthrough infection. We characterized the magnitude, phenotype and clonal composition of CD8 T cell responses against 16 epitope s...

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Literature Corpus work: 1721337b-2242-5ec8-b0b3-617506e376d6
DOI: 10.1101/2024.10.30.620795

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