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Embryonic TGF-β signaling imposes persistent changes to HSPC clonality and inflammatory landscape

2026-07-31

Abstract excerpt

Embryonic hematopoiesis is essential for establishing lifelong blood and immune system function. During development, hematopoietic stem and progenitor cells (HSPCs) acquire intrinsic programs that persist into adulthood and can influence disease susceptibility, yet the molecular signals governing these early-life decisions remain poorly understood. Here, we investigated the role of developmental Transforming Growt...

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Literature Corpus work
1717c998-044e-514e-9884-6abe17417067
DOI
10.64898/2026.07.30.741837
Open publication

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Embryonic TGF-β signaling imposes persistent changes to HSPC clonality and inflammatory landscapeDOI 10.64898/2026.07.30.741837
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