Article
Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Molecular cell - 21 Oct 2021
Abdul Rehman Syed Arif, Armstrong Lee A, Lange Sven M, Kristariyanto Yosua Adi, Gräwert Tobias W, Knebel Axel, Svergun Dmitri I, Kulathu Yogesh
Abstract excerpt
Of the eight distinct polyubiquitin (polyUb) linkages that can be assembled, the roles of K48-linked polyUb (K48-polyUb) are the most established, with K48-polyUb modified proteins being targeted for degradation. MINDY1 and MINDY2 are members of the MINDY family of deubiquitinases (DUBs) that have exquisite specificity for cleaving K48-polyUb, yet we have a poor understanding of their catalytic mechanism. Here,...
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