Article

Insertional mutagenesis in PLN <sup>R9C</sup> transgenic mouse: a case report and a review of the literature on cardiac-specific transgenic expression

2016-09-16

Abstract excerpt

A mouse line with heterozygous transgenic expression of phospholamban carrying a substitution of cysteine for arginine 9 (PLN R9C ) under the control of α-myosin heavy chain (αMHC) promoter features dilated cardiomyopathy, heart failure and premature death. In this line the transgenic array of 13 PLN R9C expression cassettes, arranged in a head-to-tail tandem orientation, has integrated into the homologous genom...

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Literature Corpus work: 170645f6-1fdc-528e-9b85-414e666f16bf
DOI: 10.1101/075671

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