Article
The contribution of non-coding regulatory elements to cardiovascular disease.
Open biology - 1 Jul 2020
Villar Diego, Frost Stephanie, Deloukas Panos, Tinker Andrew
Abstract excerpt
Cardiovascular disease collectively accounts for a quarter of deaths worldwide. Genome-wide association studies across a range of cardiovascular traits and pathologies have highlighted the prevalence of common non-coding genetic variants within candidate loci. Here, we review genetic, epigenomic and molecular approaches to investigate the contribution of non-coding regulatory elements in cardiovascular biology....
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