Article
Impedance-based phenotypic profiling of metabotropic glutamate receptor ligand responses in SCA1 human iPSC-derived neuronal cultures.
Neurobiology of disease - 1 Mar 2026
Kerkhof Laurie M C, Buijsen Ronald A M, Hartman Stefan, Pepers Barry A, van der Graaf Linda M, Frimat Jean-Philippe, Liu Rongfang, Heitman Laura H, van Roon-Mom Willeke M C
Abstract excerpt
Group 1 metabotropic glutamate receptors (mGluRs) are a family of G protein-coupled receptors (GPCRs) including mGluR1 and mGluR5. These receptors are expressed throughout the central nervous system and play an important role in synaptic plasticity. Dysfunction of mGluR1 in cerebellar Purkinje cells (PC) is observed in spinocerebellar ataxia type 1 (SCA1), an autosomal dominant neurodegenerative disorder caused...
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