Article

Convergent Transcriptomic Evidence Reveals the Dysfunctional Quantitative Mechanism of Synaptic Plasticity Control in ASD

2023-12-26

Abstract excerpt

A prominent endophenotype in Autism Spectrum Disorder (ASD) is synaptic plasticity dysfunction, yet the molecular mechanism remains elusive. As a prototype, we investigated the postsynaptic signal transduction network in glutamatergic neurons and integrated transcriptomics to unveil the malfunction of translation control. We devised an innovative and highly dependable pipeline to transform our acquired signal tran...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 167a738f-4b95-5aea-a3b8-967039c6a82d
DOI: 10.1101/2023.12.25.573326

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Convergent Transcriptomic Evidence Reveals the Dysfunctional Quantitative Mechanism of Synaptic Plasticity Control in ASDDOI 10.1101/2023.12.25.573326Read

Transcriptional Network Analysis on Brains Reveals a Potential Regulatory Role of <i>PPP1R3F</i> in Autism Spectrum DisordersSemantic proximity Read

Post-transcriptional control by RNA-binding proteins links local synaptic translation to schizophrenia genetic riskSemantic proximity Read

A computational framework linking molecular regulation, synaptic plasticity, and brain disordersSemantic proximity Read

Multiple Types of Context-Specific Brain Causal Regulatory Networks and their Applications to Autism Spectrum DisorderSemantic proximity Read

Interaction studies of risk proteins in human induced neurons reveal convergent biology and novel mechanisms underlying autism spectrum disordersSemantic proximity Read

Hidden causal inference delineates dynamic lncRNA regulation in autism spectrum disorderSemantic proximity Read

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologiesSemantic proximity Read

Cell type-specific predictive models for prioritizing genes and gene sets associated with autism spectrum disorderSemantic proximity Read

Pervasive compartment-specific regulation of gene expression during homeostatic synaptic scalingSemantic proximity Read

Post-transcriptional dysregulation in autism, schizophrenia and bipolar disorderSemantic proximity Read

Genome-Wide Changes in Protein Translation Efficiency Are Associated with Autism.Semantic proximity Read

Modelling cell type-specific lncRNA regulatory network in autism with CycleSemantic proximity Read